Research Interests
Translational research in my group is directed towards the molecular biology and cellular signalling in skin cancer with a particular emphasis on the definition and molecular regulation of cellular signalling mechanisms regulating the development and progression of melanoma. A specific focus is the regulation of apoptosis and autophagy and the contribution of these signalling mechanisms to tumour development and therapy resistance, for which we have recently identified a number of novel drug targets as well as prognostic biomarkers able to identify patient subgroups at greatest risk of disease progression.
Research is also focussed towards the development of novel translational models of skin disease, for which drug development and toxicity studies are currently on-going in collaboration with the commercial sector as well the evaluation of potential therapeutics to prevent melanoma invasion and metastasis.
Patents
P207153W0 (2014): A novel skin model to study adverse immune reactions and drug sensitivity
UK1419976.4. (2014): Ambra-1 and Loricrin as biomarkers of ulcerative melanoma
Postgraduate Research supervision
I am committed to supporting post graduate research with a proven track record in the successful career development of early/mid career researchers. I have been the primary supervisor to national and international PhD, MD, MRes, and MSc students from both clinical and non-clinical backgrounds, supervising to timely completion 10 PhD, 2 MD, 1 MSc, 3 MClin Res and >15 MRes students since 2009.
I am a Fellow of the Medical Sciences Graduate School and welcome informal enquiries from prospective doctoral or masters students.
Current PhD supervision:
- Miss Lydia Costello, BBSRC PhD studentship Durham and Newcastle Universities
- Mrs Alison Greenwood, MPhil student, Newcastle University
Previous Completed Doctoral Supervision:
- 2018 Dr Chiao-En (Peter), Wu. PhD Newcastle University
- 2018: Dr Moyassar Al Shaiban, PhD, Newcastle University
- 2017: Dr Stamatina Verykiou, CRUK Doctoral fellow, Newcastle University
- 2017: Dr Emma Woodward, BBSRC Case studentship, Newcastle University
- 2017: Dr Diana Tang, BSF Clinical Fellowship
- 2016: Dr Ashleigh Mc Connelll MRC studentship, Newcastle University
- 2013: Robert Ellis, MD, BSF Clinical Fellowship, ICM, Newcastle University
- 2013: Isabella Swindenbank, PhD, Pfizer Ltd Case Studentship, ICM, Newcastle University
- 2013: Christopher McKee, PhD, BSF studentship, ICM, Newcastle University
- 2012: Shaun Martin, PhD, CRUK Studentship, NICR/ICM, Newcastle University
- 2010: David Hill, PhD, BSF Studentship, ICM, Newcastle University
- 2010: Nigel Daniels, PhD, ICM, Newcastle University
- 2010: Quan Long, PhD, ICM, Newcastle University
Current Research
I am the principle investigator of research council, national charity and commercially funded projects, currently including:
- Translating autophagy for melanoma benefit
- Contribution of autophagy to the maintenance, invasion and metastasis of melanoma stem-like populations
- Exploiting cannabinoid-induced cytotoxic autophagy to drive melanoma cell death
- Epidermal AMBRA1 and Loricrin as prognostic biomarkers for early stage melanoma
- Targeting TGFB to prevent melanoma ulceration and metastasis
- Harnessing Autophagy for the clinical benefit of squamous cell carcinoma
- Development of prognostic biomarkers for cSCC
I am also a co investigator of other currently funded melanoma research projects and studies addressing the contribution of deregulated autophagy or apoptosis to other disease settings including Diabetes
Funding:
- NIHR
- Cancer Research UK
- The National Council for Replacement, Refinement and Reduction of animals in research
- Innovate UK
- The British Skin Foundation
- The Psoriasis Association
- The Italian Association for Cancer Research
- The Wellcome Trust
- Diabetes UK
- The Newcastle Healthcare Charity
- The Newcastle upon Tyne NHS Foundation Trust
- The JGW Patterson Foundation
- The North Eastern Skin Research Fund
- BBSRC case Phd Studentship with Astra Zeneca Ltd
- MRC/Faculty of Medical Sciences PhD studentship
Esteem Indicators
January 2018: 2018 NICE AdviSeME prize: AMBLor: A novel prognostic biomarker for early stage melanoma
June 2017: Invited lecturer: Federal University of Sao Paolo, Sao Paolo, Brazil at international meeting on Molecular Mechanisms of Autophagy and their application to Disease
May 2017: Local Organiser at annual regional UK Melanoma Focus meeting, Newcastle University, Newcastle upon Tyne, UK
May 2017: Invited speaker at COST Trans-autophagy WG4/5 workshop on Translation of Autophagy, Lisbon, Portugal
October 2016: Invited Speaker: COST ‘Trans-autophagy’ annual meeting, Warsaw, Poland
April 2016: International Guest/Invited speaker: Complutense University, Madrid, Spain
March 2015: Elected Associate Editor for The British Journal of Dermatology
November 2014: Plenary Presentation, International Society for Melanoma Research, Zurich, Switzerland
May 2014: Invited Plenary Speaker, Melanoma Focus UK, Oxford, UK
April 2014: Local Organiser of The British Society for Investigative Dermatology Annual Meeting (245 delegates)
May 2013: Invited Plenary Speaker to The International Melanoma Working Group (Chair, J Kirkwood, Pittsburgh, USA), Prague, Czechoslovakia
November 2011: Plenary Speaker, International Society for Melanoma Research, Tampa, USA
November 2011: Invited International Speaker, The National Institute of Health/National Cancer Institute Oncology Seminar Programme, Bethesda, USA
2010: Invited Panel Member of The British Skin Foundation Grants Advisory Board
September 2010: Invited External Speaker, The Blizzard Institute, London and The Bart’s Hospitals and Queen Mary University of London
September 2010: Co-organiser and lecturer for The European Society for Dermatological Research (ESDR) 'molecular biology and cell signalling' training course (Vienna, Austria)
June 2009: Invited International Plenary Speaker, European Commission FP7, Marie Curie Workshop, Rome Italy
2009: Elected Committee Member of The British Society for Investigative Dermatology
Reviewer for grant and fellowship proposals for the MRC, CRUK, BSF , Wellcome Trust, BBSRC and the European Commission
Reviewer for leading dermatology/oncology/cell signalling journals including Journal of The National Cancer Institute, Cancer Research, Journal of Investigative Dermatology, Journal of Cell Biology, Science Translational Medicine, Cell Death and Differentiation, Autophagy
